Derby della Madonnina, or the Milan Derby as it is sometimes known, is a football match between the Italian clubs A.C. Milan and F.C. Internazionale Milano (Inter). It is a hotly contested local derby and is one of the most followed derbies in football world. It is usually a semiannual fixture in the Italian football league Serie A; however, the derby has also taken place in the Coppa Italia and the UEFA Champions League.

It is called "Derby della Madonnina" in honour of one of the main sights of the city of Milan, the statue of the virgin Mary on the top of the Duomo, which is usually called "Madonnina".

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